ANTIHYPERGLYCHEMIC ACTIVITY OF SENGKUBAK (Pycnarrhena cauliflora (Miers.) Diels) LEAVES ETHANOL EXTRACT IN ALLOXAN-INDUCED MALE WHITE MICE
Abstract
Diabetes mellitus is a metabolic disorder characterized by increased blood sugar levels or hyperglycemia. The sengkubak plant (Pycnarrhena cauliflora (Miers.) Diels) which contains flavonoids, terpenoids, tannins, and saponins. This study to determine the antihyperglycemic activity of the ethanol extract of sengkubak leaves and to obtain the effective dose of the ethanolic extract of sengkubak leaves on alloxan-induced male white mice. The study used 30 male white mice (Mus musculus L.) which were divided into 6 groups normal control, negative control (CMC-Na 0.5%), and positive control (glibenclamide 0.65 mg/Kg BW), and the three test groups were given ethanol extract of mangosteen leaves with various doses of 200, 400, 800 mg/KgBW. All groups were induced with alloxan monohydrate at a dose of 70mg/KgBW in mice intraperitoneally. Sengkubak leaf extract was macerated using 96% ethanol. The parameters measured included blood sugar levels. The treatment was given for 21 days. The data obtained were analyzed using the One Way ANOVA. The results obtained are sengkubak leaf extract has antihyperglycemic activity in alloxan-induced male white mice. Sengkubak leaf extract at a dose of 800 mg/KgBW showed an effective dose in lowering blood sugar levels.References
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Burns, M., Schwinghammer, T., Wells, B., Malone, P., Kolesar, J., & DiPiro, J. (2016). Pharmacotherapy Principles & Practice (FOURTH EDI).
Cahyana, Y., & Adiyanti, T. (2021). Flavonoids as Antidiabetic Agents. 21(2), 512–526. https://doi.org/10.22146/ijc.58439
Kementerian Kesehatan Republik Indonesia. (2020). Diabetes Fakta dab Angka.
Kementrian Kesehatan Indonesia. (2017). Farmakope Herbal Indonesia Herbal. In Farmakope Herbal Indonesia Herbal (Vol. 2). https://zlibrary-id.se/s/?q=Traditional+Medicine+Strategy+2002–2005
Kementrian Kesehatan Republik Indonesia. (2018). Riset Kesehatan Dasar Nasional. Riskesdas, 76. https://www.litbang.kemkes.go.id/hasil-utama-riskesdas-2018/
Margono, R. S., & Sumiati, T. (2019). Potensi Tanaman Indonesia sebagai Antidiabetes melalui Mekanisme Penghambatan Enzim ?-glukosidase.pdf.
Masriani, Fadly, D., & Bohari. (2020). ?-Glucosidase Inhibitory Activity of Ethanol Extract Obtained From Dillenia Suffruticosa and Pycnarrhena Cauliflora. Journal of Global Pharma Technology, 12(2), 881–887.
Mulyati, B., & Penambatan, S. (2021). Studi Penambatan Molekul Flavonoid Pada Reseptor ?-Glukosidase Menggunakan Plants Flavonoid Molecular Docking Study At ?-Glucosidase Receptors Using. Jurnal Kimia Mulawarman, 18(2), 68–76.
Ningsih, D. P. C., & Santika, I. W. M. (2019). Potensi Tanaman Pinus dan Ekstraknya sebagai Penanganan Terapi pada Penyakit Diabetes dan Kardiovaskular. Prosiding Workshop Dan Seminar Nasional Farmasi, 2(October), 1–15. https://doi.org/10.3389/fendo.2019.00716
Pitriya, I. ., Nurdin, & Sabang, S. M. (2017). Efek Ekstrak Buah Kelor (Moringa Oleifera). Jurnal Akademi Kimia, 6(1), 35–42.
Puspita, D., Rahardjo, M., Setyo Wulandari, T., & Chiflyy Mandacan, D. (2019). Analisis Aktivitas Antioksidan pada Daun Kemangi Imbo (Pycnarrhena cauliflora). Prosiding Seminar Nasional Kesehatan “Transformasi Bidang Kesehatan Di Era Industri 4.0,” July, 25–29.
Saputra, M. P. A., Choesrina, R., & Mulqie, L. (2021). Studi Literatur Aktivitas Antidiabetes Ekstrak Tanaman Suku Piperaceae Secara In Vivo. Prosiding Farmasi, 642–647. https://www.academia.edu/download/99979649/30080-55966-1-PB.pdf
Sugiharto, M. I., Bintari, Y. R., & Damayanti, D. S. (2021). Mekanisme Senyawa Aktif Daun Sirsak ( Annona muricata Linn .) Sebagai Anti Diabetes?: Studi In Silico. 1–13.
Sukhikh, S., Babich, O., Prosekov, A., Kalashnikova, O., Noskova, S., Bakhtiyarova, A., Krol, O., Tsvetkova, E., & Ivanova, S. (2023). Antidiabetic Properties of Plant Secondary Metabolites. Metabolites, 13(4). https://doi.org/10.3390/metabo13040513
Wang, H., Li, N., Chivese, T., Werfalli, M., Sun, H., Yuen, L., Hoegfeldt, C. A., Elise Powe, C., Immanuel, J., Karuranga, S., Divakar, H., Levitt, Na. A., Li, C., Simmons, D., & Yang, X. (2022). IDF Diabetes Atlas: Estimation of Global and Regional Gestational Diabetes Mellitus Prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group’s Criteria. Diabetes Research and Clinical Practice, 183, 109050. https://doi.org/10.1016/j.diabres.2021.109050
Wen, W., Lin, Y., & Ti, Z. (2019). Antidiabetic, Antihyperlipidemic, Antioxidant, Anti-inflammatory Activities of Ethanolic Seed Extract of Annona reticulata L. in Streptozotocin Induced Diabetic Rats. Frontiers in Endocrinology, 10(October), 1–15. https://doi.org/10.3389/fendo.2019.00716
Published
2024-08-08
How to Cite
BILLI, Joseph; SANGGEL, Mariyo Jane; PASARIBU, Ezra.
ANTIHYPERGLYCHEMIC ACTIVITY OF SENGKUBAK (Pycnarrhena cauliflora (Miers.) Diels) LEAVES ETHANOL EXTRACT IN ALLOXAN-INDUCED MALE WHITE MICE.
Jurnal Kesehatan Borneo Cendekia, [S.l.], v. 8, n. 1, p. 81-90, aug. 2024.
ISSN 2549-1822.
Available at: <https://journal.stikesborneocendekiamedika.ac.id/index.php/jbc/article/view/522>. Date accessed: 09 sep. 2024.
doi: https://doi.org/10.54411/jbc.v8i1.522.
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